Education
Sept 2009 - present:
Wayne State University School of Medicine, Detroit, MI
Student, Master of Science program, Radiological Physics (CAMPEP-accredited)
Degree expected April 2011
-GPA as of Summer 2010: 3.70/4.00
-Additional extracurricular coursework in Cancer Biology
Sept 2008 - May 2009:
Wayne State University, Detroit, MI
Graduate Student, Physics
Sept 2004 - April 2008:
University of Michigan-Dearborn, Dearborn, MI
Bachelor of Science with High Distinction, Physics
-GPA: 3.66/4.0
-Minors: German, Mathematics
Certification Progression/Professional Memberships
2010: American Board of Radiology
Part 1 Certification in Therapeutic Radiologic Physics
2009: American Association of Physicists in Medicine
Student Member
2007: American Physical Society
Student Member
Clinical Experience
Jan 2011 - present:
IMRT QA Intern
Karmanos Cancer Institute, Detroit, MI
-Evaluated IMRT plans for radiation oncology patients on Varian iX linear accelerator with PTW Octavius phantom and VeriSoft software
-Evaluated IMRT plans for radiation oncology patients on Varian 2300EX linear accelerator with Sun Nuclear MapCHECK diode array and MapCHECK software
Mar 2011- present:
Tomotherapy DQA Intern
Karmanos Cancer Institute, Detroit, MI
•-Perform DQA on Tomotherapy plans for radiation oncology patients using Tomotherapy software and cheese phantom
Clinical Skills
-Performance of daily, weekly, and monthly QA as specified by TG-40 and TG-45 on Varian iX, 2300C/D, and 2300EX linear accelerator models
-Planning external beam radiation treatment of brain, prostate, and breast as well as total pediatric CNS treatment using Varian Eclipse software
-IMRT plan validation using Mapcheck diode array and film dosimetry
-Film analysis using Vidar film scanner and RIT software
-Performance of water tank measurements using an IBA automatic scanning system and OmniPro software
-TG-51 calibration of photon and electron beams
-LiF powder TLD measurement and analysis with Harshaw system
-PET/CT calibration
-Nuclear medicine radiation safety room survey
-Prostate seed assay, Mick cartridge loading, and treatment planning using Varian VariSeed software
-HDR ring and tandem treatment planning using Nucletron Oncentra software
-HDR source change and quarterly quality assurance
Research Experience
May 2010 - present:
Student Assistant/Research Technician, Radiobiological Physics
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Center/Wayne State University, Detroit, MI
-Assist medical residents with in vitro radiobiology experiments
-Culture, maintain, and irradiate human brain cancer cell lines to study radiosensitivity
-Perform ion chamber and film measurements on Pantak biological irradiator to establish dosage parameters for experimental setups involving different types of petri dishes and well plates
-Perform H2AX immunohistochemistry for detection of DNA double-strand breaks induced by radiation
-Established protocol for digital image analysis for DNA double-strand break quantification with ImagePro software
-Analyze colony assays using ColCount equipment and software
-Currently performing pilot experiment examining cellular uptake of fluorescently-labeled iron oxide nanoparticles for brachytherapy enhancement for NIH grant proposal
June 2007- Aug 2009:
Research Assistant
Nanomechanics Laboratory, Department of Physics and Astronomy in conjunction with Department of Pathology, School of Medicine, Wayne State University, Detroit, MI
-Developed protocol and method for the functionalization of single AFM cantilevers and mica surfaces with matrix metalloproteinase (MMP) enzymes and their inhibitors (TIMPs)
-Functionalized cantilevers and surfaces with MMPs and TIMPs
-Performed force measurements using functionalized cantilevers and surfaces to measure the rupture force between the enzymes and their inhibitors
-Assisted in performing molecular recognition force microscopy on live cells
May 2006- Aug 2009:
Research Assistant
Nanomechanics Laboratory, Department of Physics and Astronomy, Wayne State University, Detroit, MI
-Produced lipid monolayers using Langmuir-Blodgett trough and bilayers by ultrasonication
-Prepared lipid solutions from powder form
-Prepared mica substrates for deposition of lipids
-Fabricated spherically-tipped atomic force microscope (AFM) cantilevers
-Performed elasticity measurements on polyacrylamide gels used in biological research with AFM
-Imaged samples using AFM
-Performed force-distance measurements using AFM
May 2005 - April 2006:
Research Assistant
Smart Sensors and Integrated Microsystems Program, Wayne State University, Detroit, MI
-Produced various thin films using spin-coating method
-Produced metal oxide solutions of various concentrations
-Cut and prepared sapphire and graphite substrates for spin-coating
-Catalogued samples and solutions
-Used ultra-high vacuum system to anneal samples
-Analyzed samples with X-Ray Diffraction (XRD) and Superconducting Quantum Interference Device (SQUID)
-Presented data from analyses using Origin software
Presentations
June 2011
Hillman, G. G., V. Singh-Gupta, L. Runyan, C. K. Yunker, J. T. Rakowski, F. H. Sarkar, S. Miller, S. M. Gadgeel, A. A. Konski, M. C. Joiner. Soy isoflavones radiosensitize lung cancer by targeting APE1/Ref-1, NF-êB and HIF-1á survival pathways while mitigating normal tissue injury. Accepted to Wolfsberg Meeting, ESTRO, Switzerland.
May 2011
Hillman, G. G., V. Singh-Gupta, L. Runyan, C. K. Yunker, F. H. Sarkar, S. Miller, S. M. Gadgeel, M. C. Joiner, A. A. Konski. Radiosensitization of lung cancer cells by soy isoflavones involves inhibition of APE1/Ref-1 DNA repair activity. Abstract accepted to 3B Research Forum: Benchtop to Bedside and Back, ASTRO, Atlanta, GA.
Nov 2010
Ahmad, I., V. Singh-Gupta, L. Runyan, M. Joiner, J. Burmeister, and G. G. Hillman. Effect of pre-treatment imaging dose on the radiosensitivity of tumor cells. Poster presented at 52nd Annual Meeting of the American Society for Radiation Oncology, San Diego, CA.
Sept 2010
Runyan, L., V. Singh-Gupta, M. Joiner, A. A. Konski, G. G. Hillman. Soy inhibition of radiation-induced DNA repair is mediated by APE1/Ref-1 downregulation. Poster presented at Graduate Student Research Day, Wayne State University School of Medicine, Detroit, MI.
Nov 2007
Runyan, L., M. M. Bernardo, M. Pantea, E. Mayyas, V. Subba-Rao, P. M. Hoffmann, R. Fridman. Investigation of matrix metalloproteinase inhibition using atomic force microscopy. Oral presentation given at Argonne Symposium for Undergraduates in Science, Engineering, and Mathematics, A...
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