EDUCATION
Doctor of Philosophy, Biomedical Engineering Expected Graduation-May 2015
University of Arkansas, Fayetteville, AR GPA: 4.0
Bachelor of Science, Mechanical Engineering May 2011
Harding University, Searcy, AR GPA: 4.0
GPA: 4.0
EMPLOYMENT & AFFILIATIONS
Research Assistant August 2011-Present University of Arkansas, Fayetteville, AR
Laboratory for Vaccine and Immunotherapy Delivery,
Advisor: David Zaharoff
• Optimizing the binding and release of soluble chitosan for drug delivery applications by characterizing thermodynamics of binding under various conditions.
• Using viscometry to quantify the mucoadhesiveness of modified chitosans.
• Studying the treatment of bladder cancer in mice using chitosan and IL-12 as an intravesical immunotherapy.
• Elucidating the mechanisms of transfer of systemic immunity to MB49 bladder cancer after intravesical treatment with Chitosan\IL-12 using a mouse model.
Engineering Tutor September 2010-May 2011
Harding University, Searcy, AR
• Proposed, started, and ran a tutoring lab for engineering underclassmen.
• Provided help for Freshman through Junior level mechanical engineering courses.
Resident Assistant August 2008-May 2011
Harding University, Searcy, AR
• Managed 20-30 college age men in various dormitory settings for seven semesters
• Enforced regulations of the institution while maintaining a good relationship with my peers
• Learned to effectively manage diverse people in four distinct locations
Biomedical Engineering Summer Research Internship June 2010-August 2010
Virginia Tech Bioengineering and Bioinformatics Summer Institute, Blacksburg, VA
• Worked under Dr. Raffaella De Vita to improve the measurement of tensile properties of insect tracheal tubes.
• Implemented and validated digital image correlation as a form of non-contact strain measurement.
PUBLICATIONS
Bhanu prasanth Koppolu, Sean G. Smith, Sruthi Ravindranathan, Srinivas Jayanthi, T.K.S Kumar, David A. Zaharoff Controlling chitosan-based encapsulation for protein and vaccine delivery. Manuscript under review
Smith S.G., Yang L, Zaharoff D.A. (Jam. 2014) Intravesical Treatment of Orthotopic Bladder Cancer with Chitosan/IL-12 Induces Systemic Tumor-Specific Immunity. Manuscript in preparation.
Srinivas Jayanthi, Bhanu prasanth Koppolu, Sean G. Smith, Barbara K. Felber, David A. Zaharoff, and Thallapuranam Suresh Kumar One-step method for the purification of recombinant human IL-12 from mammalian cell cultures. Manuscript in preparation.
CONFERENCE PRESENATIONS
Smith, S.G, Yang, L., Zaharoff, D.A. Intravesical Chitosan/IL-12 Immunotherapy of Orthotopic Bladder Cancer Induces Tumor Specific Systemic Immunity, Biomedical Engineering Society Annual Meeting, September 25-28, 2013, Seattle, WA. (Moderated Presentation)
Smith S.G., Yang L, Zaharoff D.A. (Oct. 2012) Intravesical Treatment of Orthotopic Bladder Cancer with Chitosan/IL-12 Induces Systemic Tumor-Specific Immunity. Poster Presented at the Annual Meeting of the Society for the Immunotherapy of Cancer, Bethesda, MD.
Smith SG, S Jayanthi S, Koppolu B, Thallapuranam SK, Zaharoff DA. (Oct, 2012) Chitosan’s Milieu Alters its Interaction with Protein Biologics. Annual Meeting of the Biomedical Engineering Society, Atlanta, GA.
Smith S.G., Webster M, De Vita R. (Aug. 2010) Refining the Methods for Determining the Mechanical Properties of Insect Tracheal Tubes. Poster Presented at the Bioengineering and Bioinformatics Summer Institute, Virginia Polytechnic Institute, Blacksburg,VA.
PROFESSIONAL MEMBERSHIPS
Biomedical Engineering Society September 2011-Present
LEADERSHIP
Church Leader Part of a team that started a ministry for recent college graduates, teacher of associat...
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