Experience summary:
1. Carried out independent and extensive research in field of thrombus biology, nanobiotechnology and protein purification, chemistry and characterization leading to several multidisciplinary collaborations.
2. Findings of research are acclaimed to be path breaking in both fundamental and applied biomedical field. Research papers have very high citations and also received Young Scientist Award (2009) by Organization of Pharmaceutical Producers of India and Council of Scientific and Industrial Research in India.
3. Till date published 13 research articles, 3 sole author books and 2 book chapters.
4. Hands-on experience with wide range of lab techniques but not limited to: Handling of human blood sample and blood drawing, Electrophoresis (Native, Denaturating, Agarose etc), Western blotting, ELISA, fluorescent microscopy, TEM, Phase-contrast microscopy, Cell culture including stem cell culture, platelet aggregrometry, MALDI-TOF, Liquid NMR, cloning, expression, isolation, purification and stabilization of bacterial proteins, Isoelectric focusing and 2 D gel electrophoresis, DLS, FACS, immunoprecipitation, CD, chemical modification, Enzyme kinetics and biochemical assays, Toxicity studies and assays, protein immobilization on nanoparticles, Production of C13 and N15 labeled proteins, FTIR, UV-VIS spectroscopy, Fluorescence spectroscopy, HPLC,SEC, GPC, Affinity chromatography, handling and maintenance of mice colonies.
5. Aware of Good Manufacturing Practices (cGMP)
6. Highly motivated, analytical mind set, multitasking, able to handle different type of work responsibilities very efficiently and effective team player with excellent communication and presentation skills.
7. Have vast experience of working in multi ethnic collaborations.
Professional experience:
• Post Doctoral Research Associate (Feb. 2010 – till date)
Rensselaer Nanotechnology Center and Center for Biotechnology and Interdisciplinary studies, Rensselaer Polytechnic Institute, Troy, New York, USA
Job Summary:
1. Successfully developed a simple and sensitive technique for the determination of protein orientation on nanosurfaces employing position specific chemical modification and quantitative proteomics.
2. Used liquid NMR technique for the in depth analysis of protein structural changes induced by nanoparticles in protein-naoparticle conjugates.
3. Characterized the zinc oxide toxicity in different human cell lines (HeCat cells, Hep G2 and NSCs) an discovered that nano ZnO may modulate the cellular differentiation.
4. Developed multiple Extramural Grant Proposals.
5. Mentored 3 graduate and 5 undergraduate students.
Academic qualification:
• Ph.D. - Biochemistry (2009)
Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Title: “Studies on signal transduction mechanisms in human platelets and effect of silver nanoparticles”
• PG Diploma -Industrial program in intellectual property rights (2008, correspondence)
Bioinformatics Institute of India, Noida, India
• PG Diploma - Professional diploma in clinical research (2005)
Catalyst clinical services, New Delhi, India
• M.Sc. –Biochemistry (2004) -84.04%
Devi Ahilya University, Indore, India
• B.Sc. –Biochemistry (2002)-76.16%, Gold Medalist
Rani Durgawati University, Jabalpur, India
Publications
(A) Research Papers
1. Shrivastava S., Joseph H. Nuffer, Richard W. Siegel and Jonathan S. Dordick, “ Postion-specific chemical modification and quantitative proteomics disclose protein orientation adsorbed on silica nanoparticles”, 2012, Nano Letters (In press).
2. Shrivastava S., Jennifer E. Gagner, Jonathan S. Dordick, and Richard W. Siegel, “Nano-Bio composites for Tissue Engineering: Appraisal of Protein Interaction”, 2012, Journal of Nanoparticle Research (In press)
3. Shrivastava S., Singh S.K., and Dash D. “ Molecular signaling in platelets during fibrin clot retraction”, 2012, manuscript under revision.
4. Singh S. K., Singh M., Nayak M., Kumari S., Shrivastava S., Grccio J. and Dash D. "Thrombus inducing property of atomically thin graphene oxide sheets", 2011, ACS Nano, 5(6): 4987-4996.
5. Shrivastava S., Singh S.K., Mukhopadhyay A., Sinha A.S.K., Mandal R.K. and Dash, D. “Negative regulation of fibrin polymerization and clot formation by nanoparticles of silver”, 2011, Colloids and Surfaces B: Biointerfaces, 82(1): 241-246.
6. Shrivastava S. and Dash D. “Label-free colorimetric estimation of proteins using nanoparticles of silver”, 2010, Nano-Micro Letters, 2: 164-168.
7. Singh S.K., Shrivastava S., Sinha A.S.K., Jagannadham M., and Dash D. “Biocompatible Silver nanoparticles conjugates and stabilizes protein”, 2009, Journal of Bionanosciences, 3: 88-97.
8. Shrivastava S., Bera T., Singh S.K., Singh G., Ramachandrarao P. & Dash D. “Characterization of novel anti-platelet properties of silver nanoparticles.” 2009, ACS Nano, 3(6): 1357-1364. (Published as research highlight by journals NATURE and SCIENCE)
9. Shrivastava S. and Dash D. “Applying nanotechnology to human health”, 2009, Journal of Nanotechnology, Volume 2009, Article ID 184702, 14 pages (DOI:10.1155/2009/184702).
10. Shrivastava S. and Dash D. “Agrifood Nanotechnology: A tiny revolution in food and agriculture”, 2009, Journal of Nano Research, 6: 1 – 14.
11. Shrivastava S. “Nanofabrication for drug delivery and tissue engineering.” 2008 Digest Journal of Nanomaterials and Biostructures, 3(4): 257-263.
12. Shrivastava S. “Nanomedicine: physiological principle of distribution.” 2008 Digest Journal of Nanomaterials and Biostructures, 3(4): 303-308 INVITED ARTICLE.
13. Shrivastava S., Bera T., Roy A., Singh G., Ramachandrarao P. & Dash D. “Characterization of enhanced antibacterial effects of novel silver nanoparticles.” 2007, Nanotechnology, 18: 225103. (Published as research highlight by nanotechweb.org)
(B) Books
1. Shrivastava S., “Introductory Nano-biotechnology”, New Central Book Agency, Kolkata, India, 2012 (In Press).
2. Shrivastava S., “Signa...
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