Summary
Multi-faceted engineer interested in growing skills, the translation of research/analysis to industrial and educational use and the development of preventative interventions making use of engineering sciences.
Ten plus years of mathematical modeling experience in:
Heat/Mass/Fluid Transfer;Cell Signaling;Structural Mechanics
Education
PhD, Biomedical Engineering Drexel University, Philadelphia, PA 2015
Principle Advisor: Dr. Dov Jaron Co-Advisors: Dr. Kenneth Barbee & Dr. Donald Buerk
Thesis Title: “Nitric oxide as a regulator of blood flow in the microcirculation: A computational analysis”
MS, Mechanical Engineering Villanova University, Villanova, PA 2007
Advisor: Dr. Amy Fleischer
Thesis Title: “Influence of thermal wakes in free and forced convection on heat transfer from heat generating devices in close proximity on printed circuit boards”
BS, Mechanical Engineering Villanova University, Villanova, PA 2006
GPA: 3.8/4.0
Work Experience
Doctoral Research, Drexel University, Philadelphia, PA 2007-15
Concluded Nitric Oxide may play a role in the auto-regulation of blood flow in the microcirculation
Created a series of mathematical models allowing for the exploration of nitric oxide as a regulator of blood flow in the microcirculation.
• Computational fluid dynamic/mathematical modeling of biological systems at multiple scales.
o Nitric oxide, oxygen, blood and ATP transport
o Cellular metabolism and signaling modeling
• Systems biological studies of multiple scales of the microcirculatory system
• Application of electrophysiology and calcium handling models of smooth muscle mechanics
• Dynamic modeling of blood flow
Key Skills/Words:Mathematical Modeling of biological systems;CFD;COMSOL Multiphysics; Coupling of MATLAB to COMSOL Multiphysics;Design and analysis of experiments;Study of the cardiovascular system ;Microcirculation;Endothelial Cell mechanics ;Smooth muscle mechanics;Hemodynamics;Red blood cell transport;ATP/ADP transport and signaling;Oxygen transport and signaling;Tissue metabolism
Masters Research, Villanova University, Villanova, PA 2006-07
Determined the placement of unequally powered heat sources has a great influence on the temperature profile of a circuit board
• Computational fluid dynamics examination of the heat transfer of a multicomponent circuit board
• Parametric analysis of design features on the thermal profile of the circuit board
• Design of experiment analysis
Key Skills/Words:;Convective/Conductive heat transfer;Thermal management of electronics;Icepak;FLUENT;Design of experiments;Multi-component circuit board;CFD;
Undergraduate Research Assistant, Villanova University, Villanova, PA 2005-06
Advisor: Dr. Gerard Jones
The use of a singular imaginary node may replace the need for the calculation of view factors for radiative heat transfer problems
Key Skills/Words:Radiation heat transfer; EES software;Alternative approaches to problem solving
Undergraduate Research Assistant, Villanova University, Villanova PA 2005
Structural Engineering Teaching and Research Laboratory
• Non-destructive testing of beams.
• Designed (using Solid Works and AutoCAD) and constructed laboratory equipment (A frame to support
The design of a steel frame to support multiple MTS hydraulic systems for the testing of beams was a particular highlight)
Key Skills/Words:ANSYS; Finite Element Modeling (FEM);Design of experimental apparatus;Beam preparation for testing;Structural mechanics
Publications/Posters:
1) Kirby, P.L., Buerk, D.B.,Barbee, K.A., Jaron.D. Mathematical Model for Shear Stress Dependent NO and Adenine Nucleotide Production from Endothelial Cells. (Submitted to Nitric Oxide, In Review).
2) Andrews, A.M., Jaron, D., Buerk, D.G., Kirby, P.L. and Barbee, K.A. Direct, real-time measurement of shear stress-induced nitric oxide produced from endothelial cells in vitro. Nitric Oxide 23, 335-342, 2012.
3) Chen, X., Buerk,D.G., Barbee,K.A., Kirby, P.L. and Jaron,D. 3-D Network Model of NO Transport in Tissue. Medical and Biological Engineering and Computing 49, 6, 633-47,2011.
4) Kirby, P.L., Barbee, K.A., Buerk, D.B., Jaron.D. Dynamic Model for Shear Stress-Dependent NO and Purine Nucleotide Production from Endothelial Cells. Conference Proceedings, IUPESM World Congress on Medical Physics and Biomedical Engineering, Toronto, Canada, 2015
5) Chiobanescu Husanu, I.N., Belu,R.G., Kirby, P.L.,Gillander, J.B. Undergraduate Research Projects using Microfluidic Devices. Proceedings of the 2013 ASEE Annual Conference and Exposition, Paper Number 8172, June 23-26, Atlanta, GA, 2013.
6) Kirby, P., Fleischer, A.S. Thermal Interaction in Free Convection from Two Unequally Powered Discrete Heat Sources with Various Orientations and Separation Distances on a Vertical Plate. Proceedings of the 2007 ASME International Mechanical Engineering Congress and Exposition, Paper Number IMECE2007- 44053, November 11-15, Seattle, WA, USA, 2007.
7) Poster: Kirby, P.L., Xu,B, Mauk, M., Chiobanescu Husanu, I.N. From Benchtop To Chip: Some First Steps in Transitioning Engineering Education to the Microfluidic Scale 5th Annual Engineering Graduate R...
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